National Institute of Plant Genome Research
Digital India     
 
    Dr. Gopaljee Jha
    Staff Scientist III, Plant Microbe Interactions Lab
    PhD: Centre for Cellular and Molecular Biology, Hyderabad
    (Degree awarded by Jawaharlal Nehru University, New Delhi)
    Phone: 91-11-26741612/14/17 Extn. 177
    Direct: 91-11-26735177
    Email: jmsgopal@nipgr.ac.in
 Career
Scientist (Feb 2013-present): National Institute of Plant Genome Research, New Delhi, India.
Scientist (Aug 2007-Jan 2013): CSIR-Institute of Himalayan Bioresource Technology, Palampur, H.P, India.
Visiting Scientist (July 2010-June 2011): The Sainsbury Laboratory, John Innes Centre, Norwich, U.K.
 Award
INSA (Indian National Science Academy) medal for Young Scientist 2010
NASI (National Academy of Science, India) Platinum Jubilee Young Scientist Award 2007
BOYSCAST Fellowship from Department of Science and Technology, Govt. of India (2010-2011)
Gold Medal: Guru Nanak Dev University, Amritsar, Punjab, India
 Research

Understanding the mechanisms by which pathogens cause disease and plants defend themselves is an interesting area of research in modern biology. Important practical implications are emerging out from such researches which are helpful in strategizing plant diseases management to ensuring food security. Rice Sheath Blight disease caused by the Basidiomycete fungus Rhizoctoniasolani remains a threat to global sustainable agriculture and food security. It has complex biology and highly destructive lifestyle and has been reported occurring world-wide causing necrosis and damping-off on numerous plant species. The exact mechanisms by which this fungus establishes and maintains a necrotrophic interaction with their hosts is completely unknown. We endeavour to use the available genome sequences to identify and study the candidate pathogenicity determinant of the pathogen and explore their role in governing virulence and host specificity.  Furthermore, we would focus on understand how this pathogen manipulate rice cellular and molecular process to establish sheath blight disease.

 Career Opportunity
We are a growing lab and can provide an exciting platform for those interested in studying the molecular intricacies of host pathogen interactions. Interested and motivated people are encouraged to contact the PI for joining the lab.
 Group Members
 Selected Publications
Ghosh S, Kanwar P, and Jha G* (2017) Alterations in rice chloroplast integrity, photosynthesis and metabolome associated with pathogenesis of Rhizoctonia solani". Scientific Reports (Accepted).
Kumar R, Barman A, Phukan T, Kabyashree K, Singh N, Jha G,  Sonti R.V,  Genin S and Ray R.K. (2016). Ralstonia solanacearum virulence in tomato seedlings inoculated by leaf clipping. Plant Pathology. DOI: 10.1111/ppa.12628.
Jha G*, Tyagi I, Kumar R, and Ghosh S. (2015).Draft genome sequence of broad spectrum antifungal bacterium Burkholderia gladioli strain NGJ1, isolated from healthy rice seeds. Genome announcement. (Accepted).
Ghosh S, Gupta SK and Jha G* (2014) Identification and functional analysis of AG1-IA specific genes of Rhizoctonia solani. Current Genetics 60: 327-341. DOI: 10.1007/s00294-014-0438-x.
Kumar R, Barman A, Jha G, Ray SK (2013). Identification and establishment of genomic identity of Ralstonia solanacearum isolated from a wilted chilli plant at Tezpur, North East India. Current Science 105: 1571-1578.
Thakur K, Chawla V, Bhatti S, Swarnkar MK, Kaur J, Shankar R, Jha G* (2013).  De novo transcriptome sequencing and analysis for Venturiainaequalis, the devastating apple scab pathogen. PLoS ONE 8(1): e53937. doi:10.1371/journal.pone.0053937.
Kumar S, Haque AS, Jha G, Sonti RV and Sankaranarayanan R (2012) Crystallization and preliminary crystallographic studies on CbsA, a secretory exoglucanase from Xanthomonasoryzae pv. oryzae. ActaCrystallographica Section F. 68: 1191-1194.
Bogdanove AJ, Koebnik R, Lu H, Furutani A, Angiuoli SV, Patil PB, Van Sluys MA, Ryan RP, Meyer DF, Han SW, Aparna G, Rajaram M, Delcher AL, Phillippy AM, Puiu D, Schatz MC, Shumway M, Sommer DD, Trapnell C, Benahmed F, Dimitrov G, Madupu R, Radune D, Sullivan S, Jha G, Ishihara H, Lee SW, Pandey A, Sharma V, Sriariyanun M, Szurek B, Vera-Cruz CM, Dorman KS, Ronald PC, Verdier V, Dow JM, Sonti RV, Tsuge S, Brendel V, Rabinowicz PD, Leach JE, White FF, Salzberg SL. (2011). Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp. J. Bacteriology. 193: 5450-5464. Doi:10.1128/JB.05262-11.
Bhatti S and Jha G* (2010) Current trends and future prospects of biotechnological interventions through tissue culture in apple. Plant Cell Reports 29: 1215-1225.
Jha G, Patel H K, Dasgupta M, Palaparthi R and Sonti RV (2010) Transcriptional profiling of rice leaves undergoing a hypersensitive response like reaction induced by Xanthomonasoryzaepv. oryzaecellulase. Rice (springer). 3, 1-21. DOI 10.1007/s12284-009-9033-z. (Published in the special issue: biotic stress).
Jha G*,Thakur K and Thakur P (2009) The Venturia apple pathosystem: pathogenicity mechanisms and plant defense responses. Journal of Biomedicine and Biotechnology.   Article ID        680160, doi:10.1155/2009/680160 (A review article).
Jha G and Sonti RV (2009) Attack and defense in Xanthomonas-rice interactions. Proc. Indian NatnSciAcad 75: 49-68 (Invited Review).
Salzberg SL, Sommer DD, Schatz M C Phillippy AM, Rabinowicz PD, Tsuge S, Furutani A, Ochiai H, Delcher AL, Kelley D, Madupu R, Puiu D, Radune D, Shumway M, Trapnell C, Aparna G, Jha G, Pandey A, Patil PB, Ishihara H, Meyer DF, Szurek B, Verdier V, Koebnik R, Dow JM, Ryan RP, Hirata H, Tsuyumu S, Won Lee S, Ronald PC, Sonti RV, Van Sluys M -A, Leach JE, White FF and Bogdanove AJ (2008) Genome sequence and rapid evolution of the rice pathogen Xanthomonasoryzaepv. oryzaePXO99A. BMC Genomics 9: 204. doi:10.1186/1471-2164-9-204 (highly accessed article).
Jha G, Rajeshwari R and Sonti RV (2007) Functional interplay between two Xanthomonasoryzaepv. oryzaesecretion systems in modulating virulence on rice. Mol. Plant-Microbe Interact. 20: 31-40 (A cover page article).
Aparna G, Chatterjee A, Jha G, Sonti RV and Sankaranarayanan R (2007) Crystallization and preliminary crystallographic studies on LipA, a secreted lipase/esterase from Xanthomonasoryzaepv. oryzae. ActaCryst Sec F. F63, 708-710.
Subramoni S, Jha G, and Sonti RV (2006) Virulence functions of Xanthomonads. Book chapter in Plant Associated Bacteria, 535-571. Edited by Sam Gnanamanickam Published by Springer NL.
Jha G, Rajeshwari R and Sonti RV (2005) Bacterial type two secretion system secreted proteins: double-edged swords for plant pathogens. Mol. Plant-Microbe Interact. 18:891-898 (an invited review).
Rajeshwari R, Jha G and Sonti RV (2005) Role of an in plantaexpressed xylanase of Xanthomonasoryzaepv. oryzaein promoting virulence on Rice. Mol. Plant-Microbe Interact. 18: 830-837.
 Patents
Durga Madhab Swain, Sunil Kumar Yadav, Gopaljee Jha. 2016. Novel Protein Against Fungal Pathogens. Provisional Indian Patent Application no. 201611024726.
Pramila Yadav, Ashish Bedi, Gopaljee Jha, Subhash C Yadav. A conjugate comprising gold nanoparticles and Venturia inaequalis specific probes and kits comprising the same for the detection of apple scab. Indian Patent (File No: 361/DEL/2015)

Karnika Thakur and GopaljeeJha, Method for detecting fungal pathogens. WIPO patent pub no: WO/2011/098907

 Research in News:
Celebrating India’s National Science Day:
 http://blogs.plos.org/everyone/2013/02/28/celebrating-indias-national-science-day/